Medical Pharmacy
Clinical Pharmaceutics and Therapeutics Laboratory
Elucidation of Pharmacokinetic Variability: Role of Drug Transporters and Metabolizing Enzymes
The fate of administered drugs in the body (pharmacokinetics) shows large interindividual variability. Such pharmacokinetic variability leads to the difference in drug efficacy even when the same doses are given to patients. To accomplish the effective and safe pharmacotherapy, it is necessary to clarify the cause of interindividual variability and to individualize dosage regimen. This laboratory mainly focuses on drug transporters and metabolizing enzymes, the important determinants of pharmacokinetics. We attempt to elucidate possible factors affecting the function and expression levels of drug transporters and metabolizing enzymes, and examine these effects on pharmacokinetics and pharmacodynamics of drugs.