Life phenomena are assembly of multiple organic reactions. Breakdown in the balanced assembly in the body lead to some diseases, and we use drugs to re-establish the lance and to cure the diseases. Historically, natural products with unique chemical structure and potent bioactivity have proved to be a rich and promising source of frug candidates and chemical tools modulating biological events. So, we are executing medicinal chemistry studies based on the bioactive natural products to develop promising druf leads, together with the chemical biology research using synthetic molecular probes to elucidate their action mechanism or to find unknown biological events.