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天ヶ瀬 紀久子 天ヶ瀬 紀久子
Kikuko Amagase
Professor
Kikuko Amagase
Department
Department of Pharmacy
Laboratory
Pathological Pharmacology Laboratory
Field of Study
Biological Systems

History

Graduate School/University, etc.

Graduated from Faculty of Pharmaceutical Science, Kyoto Pharmaceutical University Completed Master’s Course in Pharmaceutical Sciences, Graduate School of Pharmaceutical Science, Kyoto Pharmaceutical University Earned Ph.D. (Pharmaceutical Sciences), Kyoto Pharmaceutical University 

研究者になったきっかけ

Why I Became a Researcher

Not long after entering graduate school, a professor in the laboratory I was affiliated with at the time said, "I will give all 100 rats that we received today to you, Ms. Amagase, so please establish an animal model for intractable gastric ulcers. Since there are ulcers that do not heal with the clinical use of gastric secretion inhibitors, I would like to present a model of this at an academic conference symposium in the fall…" And with that, my professional research life began. Since the experimental system that was decided in consultation with the professor would be as long as 8 to 12 weeks, several groups were prepared at the same time for the experiment. I was still unfamiliar with how to handle animals, so I would go to the laboratory earlier than anyone else to prepare drugs and then head to where the animals were being housed. Once all the animals were given their drugs and returned, it would already be time for lunch. As soon as lunch was over, I would go out to administer their second dose, and then I would administer their third dose in the evening…and repeat that process from there. I somehow got the data together and headed to Tokyo with the professor by bullet train. The first conference I attended was a historic and influential one, and it was only after I entered the conference hall that I realized that I actually administered drugs to animals and that the results we obtained would be presented. I was happy when the graphs and images of stomach ulcers from the results of my experiments were shown on the screen, and it made me think, “I'll do my best next year to conduct more experiments and present them myself!” After that, I returned to Kyoto on the Shinkansen and have continued like this in earnest to this very day.

Research Information

Research Area and Theme

Gastrointestinal Pharmacology and Pharmacotherapy: Pathological Analysis and Exploration of Methods of Prevention and Treatment for Various Digestive Tract Diseases

I will analyze the pathology of gastrointestinal tract injuries caused by various drugs used in clinics with the aim of proposing safer and more appropriate pharmacotherapies that reduce the amount gastrointestinal tract injuries and other side effects.

Thoughts on Research Theme

Despite their expected principal actions, therapeutic agents for various diseases that are widely used in an aging society often have a problem of causing damage to the gastrointestinal mucosa as a side effect. Therefore, I am analyzing the pathology of these drug-induced gastrointestinal tract injuries and deploying research in aim of proposing methods of prevention and treatment. Even though basic and clinical research has progressed through the development of science and technology, inflammatory bowel disease and other intractable gastrointestinal diseases have yet to be completely resolved, so along with the pathological analysis of these diseases and the deployment of research into systemic inflammatory diseases, I can expect the possibility that this research will lead to the conquering of diseases for other organs and tissues. I would like promote this research to contribute to society at large.

Message to Students

天ヶ瀬 紀久子 学生へのメッセージ 天ヶ瀬 紀久子 学生へのメッセージ

Welcome to the world of pharmaceutical sciences!

At the College of Pharmaceutical Sciences, you can learn a wide variety of disciplines, acquiring specialized skills and knowledge in the chemical, biological, physical, and medical fields, as well as the attitude that you should have as medical personnel. In other words, studying at the College of Pharmaceutical Sciences will make you into a medicinal expert who bears responsibility for medicine itself. Imagine yourself in five, ten, and twenty years from now, and in your university life, take on everything that you can, not just pharmaceutical knowledge. The more experience you have, the closer you will come to achieving your goals and making your dreams come true. As a pharmacist and scientist, communication skills are indispensable. Also, the study of pharmaceutical sciences is not limited to Japan. In order to broaden your horizons as pharmacists and scientists, it is also important to have the ability to communicate in English on equal terms with like-minded pharmacists and scientists in the world. Let's all enjoy the world of pharmaceutical sciences together!

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